It inhibits the production of hemoglobin and red blood cells. For example, people affected by milder forms of thalassemia can develop mild anemia or may have no signs or symptoms of the condition at all. General Symptoms of Thalassemia. For moderate to severe thalassemia, treatments might include: Frequent blood transfusions. [ citation needed ] Hemoglobin S /thalassemia: common in African and Mediterranean populations, is clinically similar to sickle-cell anemia , with the additional feature of splenomegaly . More severe forms of thalassemia often require frequent blood transfusions, possibly every few weeks. Intermediate forms of thalassemia can cause mild to moderate anemia and may be associated with other health problems such as slowed growth, delayed puberty, bone … A person may have alpha or beta thalassemia, and symptoms … Learn more about thalassemia, also known as Mediterranean Anemia, Cooley's Anemia or Homozygous Beta Thalassemia, and possible signs, symptoms, and treatment options for both thalassemia trait and tha Alpha Thalassemia Minor, also called Alpha Thalassemia Trait (2 genes affected). The signs and symptoms vary depending on the severity of the thalassemia. Mild forms of thalassemia trait don't need treatment. Tiredness, low energy, or muscle weakness (also called fatigue). Beta Thalassemia trait: Introduction. What if one parent has alpha thalassemia trait and the other parent is a silent carrier? Beta Thalassemia trait: Thalassemia is an inherited blood disorder characterized by abnormal synthesis of hemoglobin. Symptoms of thalassemia. Some people have little or even no symptoms. Thalassemia symptoms depend on the type of thalassemia you have and the severity of the anemia. This is why it is also sometimes referred to as Mediterranean anemia. Alpha-gene triplication is a common co-factor that may convert a thalassemia trait to a disease or worsen a benign mutation. People who have alpha thalassemia trait have red blood cells that are smaller (microcytic) and paler (hypochromic) than normal, have a decreased MCV (mean corpuscular volume, a measurement of the average size of a single red blood cell), and have a mild chronic anemia. If one parent has the cis form of alpha thalassemia trait (αα/--), and the other parent is a silent carrier (αα/α-), there is a 25 percent (1 in 4) chance with each pregnancy of having a child with hemoglobin H disease. The signs and symptoms you experience depend on the type and severity of your condition. Symptoms of thalassemia may include one or more of the following: Paleness. It leads to a decrease in overall hemoglobin levels, with the characteristic signs and symptoms of anemia.. Signs and symptoms of alpha thalassemia are those of other types of anemia and include. Some babies show signs and symptoms of thalassemia at birth, while others may develop them during the first two years of life. fatigue Your symptoms will depend on the category of thalassemia you have. Thalassemia minor generally doesn’t cause any symptoms. People who have thalassemia trait (also called thalassemia minor) carry the genetic trait for thalassemia but do not suffer from any health problems except a mild anemia. What are the Symptoms of Thalassemia? Hemoglobin E/thalassemia: common in Cambodia, Thailand, and parts of India, it is clinically similar to β thalassemia major or thalassemia intermedia. If it does, it causes minor anemia. 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